SAM decarboxylase

spinqualitylabelsall models S-adenosylmethionine decarboxylase with cofactor pyruvate complex with AdoMet 3iwc Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function S-adenosylmethionine decarboxylase (AMD) catalyzes the conversion of S-adenosylmethionine (AdoMet) to S-adenosylmethioninamine . AMD is part of the polyamine biosynthesis, in particular in the biosynthesis of spermine and spermidine from putrescine. AMD uses a covalently bound pyruvate as a cofactor. The active AMD is generated by post-translational cleavage of a precursor molecule. The cleavage results in non-identical α and β subunits and the modification of a serine residue to pyruvate. There are 2 classes of AMD. AMD I is found in bacteria and archae, AMD II is found in eukaryotes. Relevance Targeting AMD I may represent a promising strategy for pulmonary hypertension therapy. Structural insight The biological assembly of S-adenosylmethionine decarboxylase is tetramer, containing 2 α and 2 β chains. AMD active site contains residues from all protomers. The cleavage of the precursor molecule occurs at residue serine 63 which becomes a pyruvolyl group. Water molecules are shown as red spheres.

3D structures of S-adenosylmethionine decarboxylase

Updated on 01-September-2019

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• S-adenosylmethionine decarboxylase
  • 3iwb - TmAMD (mutant) + pyruvate - Thermotoga maritima
    
  • 1jen, 3ep9 – hAMD + pyruvate – human
    
  • 3ep3, 3ep4, 3ep5 - hAMD (mutant) + pyruvate
    
  • 1mhm - AMD + pyruvate – potato
• S-adenosylmethionine decarboxylase binary complex
  • 1jl0 - hAMD (mutant) + putrescine
    
  • 3iwc - TmAMD + AdoMet + pyruvate
    
  • 3iwd - TmAMD + adenosine derivative + pyruvate
    
  • 3ep6, 3ep7, 3ep8 - hAMD (mutant) + AdoMet + pyruvate
    
  • 3epa, 3epb - hAMD (mutant) + putrescine + pyruvate
    
• S-adenosylmethionine decarboxylase ternary complex
  • 1i72, 1i79, 3dz2, 3dz4, 3dz5, 3dz6, 3dz7, 3h0v, 3h0w - hAMD + adenosine derivative + putrescine + pyruvate
    
  • 1i7b - hAMD + AdoMet + putrescine + pyruvate
    
  • 3dz3 - hAMD (mutant) + AdoMet + putrescine + pyruvate
    
  • 1i7c, 1i7m - hAMD + inhibitor + putrescine + pyruvate
    
  • 5tvm, 5tvf, 6bm7 - TbAMD + AMD proenzyme-like + inhibitor + putrescine + pyruvate - Trypanosoma brucei
    
• S-adenosylmethionine decarboxylase precursor
  • 1tlu, 1vr7 - TmAMD
    
  • 1tmi - TmAMD (mutant)
    
  • 2iii – AMD – Aquifex aeolicus
    
  • 1msv - hAMD (mutant) + putrescine
    
  • 5tvo - TbAMD + pyruvate
    

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman