Thiolase

spinqualitylabelsall models Human 3-ketoacyl-CoA complex with CoA and ethylene glycol(PDB code 4c2j). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Two different classes of thiolases are found. Degrative thiolase like 3-ketoacyl-CoA thiolase (KCT) is involved in fatty acid β oxidation. Biosynthetic thiolases like acetoacetyl-CoA thiolase (ACT) are involved in the thiolysis of acetoacetyl-CoA. For Bacterial thiolase see Bacterial thiolase Structural highlights The active site of 3-ketoacyl-CoA thiolase contains CoA. Water molecules are shown as red spheres.

3D Structures of Thiolase

Updated on 22-September-2019

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• 3-ketoacyl-CoA thiolase
  • Bacterial thiolase, 2c7y, 2c7z – KCT peroxisomal residues 36-462 – Arabidopsis thaliana
    
  • 2wua - KCT peroxisomal residues 17-449 (mutant) – sunflower
    
  • 2iik – hKCT peroxisomal – human
    
  • 4c2k – hKCT mitochondrial
    
  • 4c2j – hKCT mitochondrial + CoA
    
  • 3goa – KCT – Salmonella typhimurium
    
  • 5lp7 – KCT – Bacillus subtilis
    
  • 1afw, 1pxt – yKCT peroxisomal – yeast
    
  • 5cbq – MsKCT – Mycobacterium smegmatis
    
  • 4w61 – ReKCT – Ralstonia eutropha
    
  • 4ubw, 5onc – MtKCT – Mycobacterium tuberculosis
    
• 3-ketoacyl-CoA thiolase complex
  • 3w15 - yKCT peroxisomal residues 27-396 + peroxiomal membrane protein PEX21 + peroxisomal targeting signal receptor
    
  • 2d3t – PfKCT + fatty oxidation complex β subunit – Pseudomonas fragi
    
  • 1wdk, 1wdl, 1wdm - PfKCT + fatty oxidation complex α subunit
    
  • 5bz4 – MsKCT + CoA
    
  • 4ubt – MtKCT (mutant) + CoA + steroid
    
  • 4ubu – MtKCT (mutant) + CoA
    
  • 4ubv – MtKCT + CoA + acetyl CoA
    
• Acetoacetyl-CoA thiolase or acetyl-CoA acetyltransferase
  • 1m4s, 1m4t, 1dlu, 1qfl - ZrACT – Zoogloea ramigera
    
  • 2wku, 2wl6, 1m1t, 1m3k - ZrACT (mutant)
    
  • 2ib7, 2ib8, 2ib9, 2ibu, 2ibw, 2iby, 2f2s – hACT mitochondrial
    
  • 1wl5 - hACT cytosolic
    
  • 4dd5, 4e1l – ACT – Clostridium difficile
    
  • 4xl2, 4xl3, 4n44, 4n45 – CaACT – Clostridium acetobutylicum
    
  • 4wyr – CaACT (mutant)
    
  • 5f0v, 5f38, 4wys – ACT – Escherichia coli
    
  • 4o9a, 4o99, 4o9c, 4nzs – ReACT
    
  • 5xyj, 5xz5 – yACT
    
• Acetoacetyl-CoA thiolase complex
  • 1dm3, 1dlv – ZrACT + CoA
    
  • 2wkt, 2wkv, 2wl4, 2wl5, 2vtz, 1m3z – ZrACT (mutant) + CoA
    
  • 1m1o - ZrACT (mutant) + acetoacetyl-CoA
    
  • 2vu0, 1nl7 - ZrACT + CoA
    
  • 2vu1, 2vu2, 1ou6 - ZrACT + pantheteine-11-pivalate
    
  • 1wl4 – hACT cytosolic + CoA
    
  • 4xl4 – CaACT + CoA
    
  • 6et9 – MtACT + PFAM DUF35 + hydroxymethylglutaryl-CoA synthase - Methanothermococcus thermolithotrophicus
    
  • 6esq – MtACT + CoA + PFAM DUF35 + hydroxymethylglutaryl-CoA synthase
    
  • 6are – ACT + CoA + acetate - Aspergillus fumigatus
    

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