TRAIL

spinqualitylabelsall models Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, 1d0g Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function TRAIL (TNF-related apoptosis-inducing ligand) or TNF ligand superfamily 10 functions as a ligand in the process of apoptosis. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see Molecular Playground/TRAIL. TRAIL trimer residues complex with death receptor-5 extracellular domain (1d0g). Zn+2 and Cl-1 bind to 3 same Cys residues from different subunits of TRAIL trimer. Disease TRAIL concentrations are reduced in rheumatoid arthritis.

3D Structures of TRAIL

Molecular Playground/TRAIL, 1d0g, 1du3, 5cir - hTRAIL extracellular domain + DR5 extracellular domain - human
1dg6 – hTRAIL jelly-roll domain
1d2q - hTRAIL extracellular domain
4n90 - hTRAIL extracellular domain + DR5 extracellular domain + antibody

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky