6jcs | pdb_00006jcs
AAV5 in complex with AAVR
Structural highlights
Disease[K319L_HUMAN] Systemic lupus erythematosus;Limited cutaneous systemic sclerosis. Function[K319L_HUMAN] Possible role in axon guidance through interaction with RTN4R.[1] Publication Abstract from PubMedAdeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, revealing the molecular details by which PKD1 recognizes AAV5 and PKD2 is solely engaged with AAV1. PKD2 lies on the plateau region of the AAV1 capsid. However, the AAV5-AAVR interface is strikingly different, in which PKD1 is bound at the opposite side of the spike of the AAV5 capsid than the PKD2-interacting region of AAV1. Residues in strands F/G and the CD loop of PKD1 interact directly with AAV5, whereas residues in strands B/C/E and the BC loop of PKD2 make contact with AAV1. These findings further the understanding of the distinct mechanisms by which AAVR recognizes various AAV serotypes and provide an example of a single receptor engaging multiple viral serotypes with divergent rules. Divergent engagements between adeno-associated viruses with their cellular receptor AAVR.,Zhang R, Xu G, Cao L, Sun Z, He Y, Cui M, Sun Y, Li S, Li H, Qin L, Hu M, Yuan Z, Rao Z, Ding W, Rao Z, Lou Z Nat Commun. 2019 Aug 21;10(1):3760. doi: 10.1038/s41467-019-11668-x. PMID:31434885[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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