6eno | pdb_00006eno

Double cubane cluster oxidoreductase

spinqualitylabelsall models 6eno, resolution 1.64Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6eno is a 1 chain structure with sequence from Carhz. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BJ8, CIT, GOL Gene: CHY_0487 (CARHZ) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Chemically demanding reductive conversions in biology, such as the reduction of dinitrogen to ammonia or the Birch-type reduction of aromatic compounds, depend on Fe/S-cluster-containing ATPases. These reductions are typically catalyzed by two-component systems, in which an Fe/S-cluster-containing ATPase energizes an electron to reduce a metal site on the acceptor protein that drives the reductive reaction. Here, we show a two-component system featuring a double-cubane [Fe8S9]-cluster [{Fe4S4(SCys)3}2(mu2-S)]. The double-cubane-cluster-containing enzyme is capable of reducing small molecules, such as acetylene (C2H2), azide (N3(-)), and hydrazine (N2H4). We thus present a class of metalloenzymes akin in fold, metal clusters, and reactivity to nitrogenases. ATP-dependent substrate reduction at an [Fe8S9] double-cubane cluster.,Jeoung JH, Dobbek H Proc Natl Acad Sci U S A. 2018 Mar 5. pii: 1720489115. doi:, 10.1073/pnas.1720489115. PMID:29507223 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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