MECDP synthase

spinqualitylabelsall models Se-Met MECDP synthase trimer complex with CDP, sulfate, Mn+2 (purple) and Zn+2 (grey) ion, 1gx1 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function MECDP synthase or 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS) participates in mevalonate-independent steroid biosynthesis. It converts 2-phospho-4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol (2P-CDME) to 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate (MECP) and CMP. MECPS contains metal binding sites which are required for catalysis. Relevance MECPS is a potential antimalarial drug target. Structural highlights MECPS active site is located in a cleft between 2 subunits and contains the metal ions. Water molecules are shown as red spheres. 3D structures of MECDP synthase MECDP synthase 3D structures

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