6e7l | pdb_00006e7l

Structure of a dimerized UUCG motif

spinqualitylabelsall models 6e7l, resolution 2.59Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6e7l is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The structure of a 22-base-pair RNA helix with mismatched pyrimidine base pairs is reported. The helix contains two symmetry-related CUG sequences: a triplet-repeat motif implicated in myotonic dystrophy type 1. The CUG repeat contains a U-U mismatch sandwiched between Watson-Crick pairs. Additionally, the center of the helix contains a dimerized UUCG motif with tandem pyrimidine (U-C/C-U) mismatches flanked by U-G wobble pairs. This region of the structure is significantly different from previously observed structures that share the same sequence and neighboring base pairs. The tandem pyrimidine mismatches are unusual and display sheared, cross-strand stacking geometries that locally constrict the helical width, a type of stacking previously associated with purines in internal loops. Thus, pyrimidine-rich regions of RNA have a high degree of structural diversity. Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking.,Montemayor EJ, Virta JM, Hagler LD, Zimmerman SC, Butcher SE Acta Crystallogr F Struct Biol Commun. 2019 Oct 1;75(Pt 10):652-656. doi:, 10.1107/S2053230X19012172. Epub 2019 Sep 24. PMID:31584014 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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