1lis | pdb_00001lis

THE CRYSTAL STRUCTURE OF A FERTILIZATION PROTEIN

spinqualitylabelsall models 1lis, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1lis is a 1 chain structure with sequence from California red abalone. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [ELYS_HALRU] Dissolves the egg vitelline layer nonenzymatically during fertilization. It creates a hole of about 3 mu-m in diameter through which the sperm pass. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Lysin, a protein from abalone sperm, creates a hole in the envelope of the egg, permitting the sperm to pass through the envelope and fuse with the egg. The structure of lysin, refined at 1.9 angstroms resolution, reveals an alpha-helical, amphipathic molecule. The surface of the protein exhibits three features: two tracks of basic residues that span the length of the molecule, a solvent-exposed cluster of aromatic and aliphatic amino acids, and an extended amino-terminal hypervariable domain that is species-specific. The structure suggests possible mechanisms of action. The crystal structure of lysin, a fertilization protein.,Shaw A, McRee DE, Vacquier VD, Stout CD Science. 1993 Dec 17;262(5141):1864-7. PMID:8266073 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Lysin

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