Sandbox GGC7

Structure E28A mutant of the HIV-1

Mutant of the HIV-1 Capsid p

spinqualitylabelsall models Triose phosphate isomerase Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Spacefill mutant HIV-1 Ca Hexamer interfaces Function The function of the HIV-1 capsid protein is to encapsidate and protect the viral RNA genome. It contains important sites on its surface that allow the virion to be attach to the host cell. The CA protein a key has an important role in early and late stages of the HIV virus replication cycle. The HIV capsid is built from a single protein, known as capsid protein (CA). The protein folds to form two domains the N-terminal and C-terminal connected by a small flexible linker. Disease HIV infection (Human Immunodeficiency virus) The virus attacks the cells in the body that help to fight infection, causing weakness in the immune system and making the person’s liable for any infection or disease. HIV can be spread by unprotected intercourse, blood, breast milk, body fluids. Relevance The studies of the HIV capsid in this case Mutagenesis and structural experiments have revealed that capsid core stability affects uncoating and initiation of reverse transcription in host cells. The studies have led to efforts in developing antivirals targeting the capsid protein and its assembly. Structural highlights The structure on the scene is the E28A mutant of the HIV-1 Capsid protein. The green balls are the Cl ion and the purple are Iodide ions. The structure was loaded and the color was changed to model the 6 chains connected together by a flexible linker to form the hexamers which encloses the viral RNA.

References

https://proteopedia.org/wiki/index.php/5w4p https://www.rcsb.org/structure/5W4P