5kd1 | pdb_00005kd1

Sperm whale myoglobin H64A with nitrosoamphetamine

spinqualitylabelsall models 5kd1, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5kd1 is a 1 chain structure with sequence from Phymc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 3QM, GOL, HEM, SO4 Gene: MB (PHYMC) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [MYG_PHYCD] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Publication Abstract from PubMed N-hydroxyamphetamine (AmphNHOH) is an oxidative metabolite of amphetamine and methamphetamine. It is known to form inhibitory complexes upon binding to heme proteins. However, its interactions with myoglobin (Mb) and hemoglobin (Hb) have not been reported. We demonstrate that the reactions of AmphNHOH with ferric Mb and Hb generate the respective heme-nitrosoamphetamine derivatives characterized by UV-vis spectroscopy. We have determined the X-ray crystal structure of the H64A Mb-nitrosoamphetamine complex to 1.73 A resolution. The structure reveals the N-binding of the nitroso-d-amphetamine isomer, with no significant H-bonding interactions between the ligand and the distal pocket amino acid residues. Nitrosoamphetamine binding to myoglobin and hemoglobin: Crystal structure of the H64A myoglobin-nitrosoamphetamine adduct.,Wang B, Powell SM, Guan Y, Xu N, Thomas LM, Richter-Addo GB Nitric Oxide. 2017 Apr 24;67:26-29. doi: 10.1016/j.niox.2017.04.012. PMID:28450187 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Myoglobin 3D structures

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