5cay | pdb_00005cay

Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor

spinqualitylabelsall models 5cay, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5cay is a 2 chain structure with sequence from Hiv-2 and Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BMA, NAG Gene: CD4 (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CD4_HUMAN] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Publication Abstract from PubMed HIV-2 is a non-pandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term non-progression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30-40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0 A structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence. Structure of an HIV-2 gp120 in complex with CD4.,Davenport YW, West AP Jr, Bjorkman PJ J Virol. 2015 Nov 25. pii: JVI.02678-15. PMID:26608312 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also CD4 3D structures Gp120 3D structures Immunodeficiency virus protease 3D structures

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