1tdo | pdb_00001tdo

L-amino acid oxidae from Agkistrodon halys in complex with L-phenylalanine

spinqualitylabelsall models 1tdo, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1tdo is a 1 chain structure with sequence from Gloydius halys. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FAD, NAG, NDG, PHE Related: 1tdk, 1tdn Activity: L-amino-acid oxidase, with EC number 1.4.3.2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [OXLA_GLOBL] Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as apoptosis, and inhibition of agonist- and shear stress-induced platelet aggregation (SIPA). Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions. This protein may also induce hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Amino acid oxidase 3D structures

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