4f8u | pdb_00004f8u

Crystal structure of the bacterial ribosomal decoding site in complex with sisomicin (C2 form)

spinqualitylabelsall models 4f8u, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4f8u is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SIS Related: 4f8v Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Sisomicin with an unsaturated sugar ring I displays better antibacterial activity than other structurally related aminoglycosides, such as gentamicin, tobramycin, and amikacin. In the present study, we have confirmed by X-ray analyses that the binding mode of sisomicin is basically similar but not identical to that of the related compounds having saturated ring I. A remarkable difference is found in the stacking interaction between ring I and G1491. While the typical saturated ring I with a chair conformation stacks on G1491 through CH/pi interactions, the unsaturated ring I of sisomicin with a partially planar conformation can share its pi-electron density with G1491 and fits well within the A-site helix. Crystal structure and specific binding mode of sisomicin to the bacterial ribosomal decoding site.,Kondo J, Koganei M, Kasahara T ACS Med Chem Lett. 2012 Aug 2;3(9):741-4. doi: 10.1021/ml300145y. eCollection, 2012 Sep 13. PMID:24900542 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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