Structural highlights
5uzs is a 4 chain structure with sequence from Clop1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | 8L4, EDO, IMP, K, MG, PEG, PG4, PGE |
| NonStd Res: | ALY |
| Related: | 4q32, 4q33, 5uwx, 5uxe, 5uze, 5uzc, 5uzo |
| Gene: | guaB, CPF_2558 (CLOP1) |
| Activity: | IMP dehydrogenase, with EC number 1.1.1.205 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[A0A0H2YRZ7_CLOP1] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
See Also
