5x45 | pdb_00005x45

Crystal structure of 2A protease from Human rhinovirus C15

spinqualitylabelsall models 5x45, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5x45 is a 4 chain structure with sequence from Human rhinovirus c. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The majority of outbreaks of the common cold are caused by rhinoviruses. The 2A protease (2A(pro)) of human rhinoviruses (HRVs) is known to play important roles in the propagation of the virus and the modulation of host signal pathways to facilitate viral replication. The 2A(pro) from human rhinovirus C15 (HRV-C15) has been expressed in Escherichia coli and purified by affinity chromatography, ion-exchange chromatography and gel-filtration chromatography. The crystals diffracted to 2.6 A resolution. The structure was solved by molecular replacement using the structure of 2A(pro) from coxsackievirus A16 (CVA16) as the search model. The structure contains a conserved His-Asp-Cys catalytic triad and a Zn(2+)-binding site. Comparison with other 2A(pro) structures from enteroviruses reveals that the substrate-binding cleft of 2A(pro) from HRV-C15 exhibits a more open conformation, which presumably favours substrate binding. Structural view of the 2A protease from human rhinovirus C15.,Ling H, Yang P, Hou H, Sun Y Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):255-261. doi:, 10.1107/S2053230X18003382. Epub 2018 Mar 28. PMID:29633974 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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