6jat | pdb_00006jat

Crystal structure of SETD3 bound to Actin peptide and SFG

spinqualitylabelsall models 6jat, resolution 2.71Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6jat is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EPE, SFG, SO4 Activity: Histone-lysine N-methyltransferase, with EC number 2.1.1.43 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [ACTH_HUMAN] Myopathic intestinal pseudoobstruction;Megacystis-microcolon-intestinal hypoperistalsis syndrome;Familial visceral myopathy. The disease is caused by mutations affecting the gene represented in this entry. Function [SETD3_HUMAN] Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). [ACTH_HUMAN] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

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