4ajf | pdb_00004ajf

Identification and structural characterization of PDE10 fragment inhibitors

spinqualitylabelsall models 4ajf, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ajf is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: F03, MG, ZN Related: 1lrb, 2wey, 2y0j, 4ael, 4ajd, 4ajg, 4ajm Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. See Also Phosphodiesterase 3D structures

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