6sgm | pdb_00006sgm

Crystal structure of monooxygenase RutA complexed with 4-Thiouracil.

spinqualitylabelsall models 6sgm, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6sgm is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FMN, LDB Related: 6sgg, 6sgj, 6sgl Activity: Oxidoreductase, with EC number 1.14.99.46 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [RUTA_ECOLI] Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. Requires the flavin reductase RutF to regenerate FMN in vivo. RutF can be substituted by Fre in vitro.

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