4hjc | pdb_00004hjc

Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)

spinqualitylabelsall models 4hjc, resolution 4.15Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4hjc is a 1 chain structure with sequence from Rvfv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 4hj1 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Rift Valley fever virus (RVFV), like many other Bunyaviridae family members, is an emerging human and animal pathogen. Bunyaviruses have an outer lipid envelope bearing two glycoproteins, G(N) and G(C), required for cell entry. Bunyaviruses deliver their genome into the host-cell cytoplasm by fusing their envelope with an endosomal membrane. The molecular mechanism of this key entry step is unknown. The crystal structure of RVFV G(C) reveals a class II fusion protein architecture found previously in flaviviruses and alphaviruses. The structure identifies G(C) as the effector of membrane fusion and provides a direct view of the membrane anchor that initiates fusion. A structure of nonglycosylated G(C) reveals an extended conformation that may represent a fusion intermediate. Unanticipated similarities between G(C) and flavivirus envelope proteins reveal an evolutionary link between the two virus families and provide insights into the organization of G(C) in the outer shell of RVFV. Crystal structure of glycoprotein C from Rift Valley fever virus.,Dessau M, Modis Y Proc Natl Acad Sci U S A. 2013 Jan 14. PMID:23319635 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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