6tug | pdb_00006tug

Enterococcus italicus Csm6 bound to cyclic hexa-2'-fluoro-hexa-dAMP

spinqualitylabelsall models 6tug, resolution 2.42Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6tug is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: AF2, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CSM6_ENTI1] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities. In a heterologous host the appropriately targeted Csm effector complex prevents growth of dsDNA phage phiNM1-gamma6. This protein is not part of the Csm effector complex (PubMed:28722012). A single-strand-specific endoribonuclease (ssRNase) (PubMed:28722012). Activity is stimulated by cyclic oligoadenylates (cOA); maximal stimulation is seen with cyclic hexaadenylate (cA6) (PubMed:28722012).

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