TNF receptor-associated factor

spinqualitylabelsall models Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code 1f3v) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function TNF receptor-associated factor (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins. TRAF1 is the only TRAF which does not have N-terminal RING and zinc finger motifs. TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK. TRAF3 mediates some innate immune receptor signals and regulates some post-translational modifications. TRAF4 is a binding partner of glycoproteins in platelets. Structural highlights The interaction of TRAF2 with the adaptor protein TRADD is bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions. Hydrophobic, Polar 3D Structures of TNF receptor-associated factor TNF receptor-associated factor 3D structures

3D Structures of TNF receptor-associated factor

Updated on 27-February-2020

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• TRAF1; domains – RING 66-124; zinc finger 1-3 125-211; ZF-TRAF 190-248; TRAF 348-504
  • TNF receptor-associated factor 3D structures – hTRAF1 TRAF domain - human
    
  • 3m0d – hTRAF1 residues 266-329 + hTRAF2 + cIAP2
    
  • 5h10 – hTRAF1 TRAF domain + TANK peptide
    
• TRAF2
  • 1ca4 – hTRAF2 TRAF domain
    
  • 3knv – hTRAF2 RING+zinc finger 1 domains
    
  • 3m06 – hTRAF2 residues 266-329
    
• TRAF2 complex with peptide
  • 1ca9 – hTRAF2 TRAF domain + TNF-R2 peptide
    
  • 1qsc, 1d00, 1czz – hTRAF2 TRAF domain + CD40 receptor peptide
    
  • 1d01 – hTRAF2 TRAF domain + CD30 peptide
    
  • 1czy – hTRAF2 TRAF domain + latent membrane protein peptide
    
  • 1d0a – hTRAF2 TRAF domain + OX40L receptor peptide
    
  • 1d0j – hTRAF2 TRAF domain + 4-1BB ligand receptor peptide
    
  • 1f3v – hTRAF2 TRAF domain + TRADD N terminal
    
  • 3m0a – hTRAF2 residues 266-329 + cIAP2
    
• TRAF3
  • 2ecy – hTRAF3 RING domain - NMR
    
  • 1flk – hTRAF3 TRAF domain
    
  • 2gkw – hTRAF3 TRAF domain + BAFF receptor peptide
    
  • 1zms – hTRAF3 TRAF domain + LMP1 peptide
    
  • 1rf3 – hTRAF3 TRAF domain + lymphotoxin receptor peptide
    
  • 1kzz – hTRAF3 TRAF domain + TANK peptide
    
  • 1l0a – hTRAF3 TRAF domain (mutant) + TANK peptide
    
  • 1fll – hTRAF3 TRAF domain + CD40 peptide
    
  • 4ghu – TRAF3 TRAF domain + antiviral-signaling protein peptide - mouse
    
• TRAF4
  • 4k8u, 3zjb, 4m4e – hTRAF4 TRAF domain
    
  • 2eod – hTRAF4 ZF-TRAF domain - NMR
    
  • 2yuc – hTRAF4 zinc finger 1 domain - NMR
    
  • 5yc1 – hTRAF4 TRAF domain + GLIB peptide
    
• TRAF5
  • 4gjh – hTRAF5 TRAF domain
    
• TRAF6; domains: RING 50-124; zinc finger 1 125-159;zinc fingers 2,3 160-211; TRAF 346-504
  • 1lb4 – hTRAF6 TRAF domain
    
  • 2jmd, 2eci – hTRAF6 RING domain - NMR
    
  • 3hcs – hTRAF6 RING+zinc finger 1-3 domains
    
• TRAF6 complex with peptide
  • 1lb5 – hTRAF6 TRAF domain + RANK peptide
    
  • 1lb6 – hTRAF6 TRAF domain + CD40 antigen peptide
    
  • 3hct, 3hcu – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2
    
  • 4z8m – hTRAF6 TRAF domain + antiviral-signaling protein peptide
    
  • 6a33, 5zuj – hTRAF6 TRAF domain + TIFA peptide
    
  • 5vnz, 5vo0 – zfTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2 - zebrafish
    
  • 6myd – zfTRAF6 TRAF domain + STING CTT peptide
    

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