3jc2 | pdb_00003jc2

The structure of the mammalian Sec61 channel opened by a signal sequence

Loading... Status: waiting for Mol* initialization Structural highlights 3jc2 is a 4 chain structure with sequence from Bovin and Canis lupus familiaris. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: UNK Gene: prolactin (BOVIN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Secreted and integral membrane proteins compose up to one-third of the biological proteome. These proteins contain hydrophobic signals that direct their translocation across or insertion into the lipid bilayer by the Sec61 protein-conducting channel. The molecular basis of how hydrophobic signals within a nascent polypeptide trigger channel opening is not understood. Here, we used cryo-electron microscopy to determine the structure of an active Sec61 channel that has been opened by a signal sequence. The signal supplants helix 2 of Sec61alpha, which triggers a rotation that opens the central pore both axially across the membrane and laterally toward the lipid bilayer. Comparisons with structures of Sec61 in other states suggest a pathway for how hydrophobic signals engage the channel to gain access to the lipid bilayer. Structure of the Sec61 channel opened by a signal sequence.,Voorhees RM, Hegde RS Science. 2016 Jan 1;351(6268):88-91. doi: 10.1126/science.aad4992. PMID:26721998 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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