Structural highlights
Disease[GCYA1_HUMAN] Moyamoya disease with early-onset achalasia. The disease is caused by mutations affecting the gene represented in this entry. Publication Abstract from PubMedSoluble guanylate cyclase (sGC) is the primary sensor of nitric oxide. It has a central role in nitric oxide signalling and has been implicated in many essential physiological processes and disease conditions. The binding of nitric oxide boosts the enzymatic activity of sGC. However, the mechanism by which nitric oxide activates the enzyme is unclear. Here we report the cryo-electron microscopy structures of the human sGCalpha1beta1 heterodimer in different functional states. These structures revealed that the transducer module bridges the nitric oxide sensor module and the catalytic module. Binding of nitric oxide to the beta1 haem-nitric oxide and oxygen binding (H-NOX) domain triggers the structural rearrangement of the sensor module and a conformational switch of the transducer module from bending to straightening. The resulting movement of the N termini of the catalytic domains drives structural changes within the catalytic module, which in turn boost the enzymatic activity of sGC. Structural insights into the mechanism of human soluble guanylate cyclase.,Kang Y, Liu R, Wu JX, Chen L Nature. 2019 Oct;574(7777):206-210. doi: 10.1038/s41586-019-1584-6. Epub 2019 Sep, 12. PMID:31514202[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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