6pvo | pdb_00006pvo

Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 37 degrees Celsius

Loading... Status: waiting for Mol* initialization Structural highlights 6pvo is a 4 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: Trpv3 (LK3 transgenic mice) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [TRPV3_MOUSE] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity). Publication Abstract from PubMed We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo alpha-to-pi transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains. Structural basis of temperature sensation by the TRP channel TRPV3.,Singh AK, McGoldrick LL, Demirkhanyan L, Leslie M, Zakharian E, Sobolevsky AI Nat Struct Mol Biol. 2019 Oct 21. pii: 10.1038/s41594-019-0318-7. doi:, 10.1038/s41594-019-0318-7. PMID:31636415 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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