Troponin

spinqualitylabelsall models Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) 1yv0 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Troponin (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits: TnC causes conformational change in TnI when it binds to calcium ions. For more details on TnC see Role of Troponin C in decreased muscle sensitivity to calcium Human Cardiac Troponin C Human Cardiac Troponin C in complex with the Green Tea Polyphenol TnT binds to tropomyosin. TnI binds to actin which is found in thin muscle filaments. Disease Mutations in TnI and TnT are associated with hypertrophic cardiomyopathy.

3D Structures of Troponin

Updated on 10-March-2020

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• Troponin C+Troponin I+Troponin T
  • Role of Troponin C in decreased muscle sensitivity to calcium, Human Cardiac Troponin C, Human Cardiac Troponin C in complex with the Green Tea Polyphenol – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human
    
  • tropomyosin, 6kn7 - hTnC + hTnI + hTnT + actin + tropomyosin – Cryo EM
    
  • 6klu, 6klt - mTnC + TnI + TnT – mouse - Cryo EM
    
  • 2w49, 2w4u – cTnC+cTnI+cTnT+tropomyosin+actin – chicken
    
  • 1ytz - cTnC+cTnI+cTnT+Ca
    
  • 1yv0 - cTnC+cTnI+cTnT
    
• Troponin C+Troponin I
  • 2krd, 2mkp – hTnC+hTnI + Ca – NMR
    
  • 6mv3 – hTnC/hTnI (mutant) – NMR
    
  • 1ozs - hTnC C-terminal+hTnI N-terminal – NMR
    
  • 2l1r - hTnC C-terminal+hTnI switch region - NMR
    
  • 1lxf, 1mxl - hTnC N-terminal+hTnI fragment - NMR
    
  • 2n7l - hTnC N-terminal/hTnC switch + drug analog – NMR
    
  • 2kgb – hTnC (mutant) regulatory domain+TnI - NMR
    
  • 2mzp - hTnC regulatory domain+TnI switch region (mutant) - NMR
    
  • 1a2x - rTnC +rTnI fragment – rabbit
    
  • 1sbj – cTnC C-terminal+cTnI N-terminal+Mg - NMR
    
  • 1scv, 1fi5, 1blq - cTnC C-terminal+cTnI N-terminal – NMR
    
  • 1npq - cTnC (mutant) N-terminal+cTnI fragment+rhodamine
    
  • 1jc2 - cTnC C-terminal+cTnI N-terminal
    
  • 3tz1 - TnC C terminal +TnI fragment – akazara scallop
    
• Troponin C
  • 2kdh – hTnC+green tea polyphenol – NMR
    
  • 2jt0, 2jtz, 2jt8, 2jt3 – hTnC (mutant) – NMR
    
  • 3rv5, 3sd6, 3swb, 4gje, 1spy - hTnC N-terminal
    
  • 4gjg, 5vln - hTnC N-terminal (mutant)
    
  • 1ap4 - hTnC N-terminal+Ca – NMR
    
  • 2jxl, 2n79 - hTnC N-terminal (mutant) + Ca – NMR
    
  • 4gjf - hTnC N-terminal (mutant) + Cd
    
  • 1wrk, 1wrl - hTnC N-terminal (mutant) +trifluoperazine
    
  • 5w88, 5wcl - hTnC N-terminal (mutant) + methyldiphenylamine - NMR
    
  • 2kfx – hTnC (mutant) N-terminal+Ca+naphthalene derivative
    
  • 2mle - hTnC C-terminal – NMR
    
  • 2mlf - hTnC C-terminal (mutant) – NMR
    
  • 1ih0 - hTnC C-terminal+EMD 57033 – NMR
    
  • 2l98 – hTnC EF-hand domains 3,4 + resveratrol
    
  • 1tcf – rTnC+Ca
    
  • 1tn4, 2tn4 – rTnC (mutant)+Ca
    
  • 1la0, 4tnc – cTnC+Ca
    
  • 1dtl – cTnC (mutant)+Ca +bepridil
    
  • 1skt, 1zac, 2ctn - cTnC N-terminal – NMR
    
  • 1aj4 - cTnC (mutant) +Ca – NMR
    
  • 3ctn - cTnC C-terminal – NMR
    
  • 1avs - cTnC N-terminal+Ca
    
  • 1smg, 1tnq - cTnC N-terminal+Ca - NMR
    
  • 1ncy – cTnC+Mn
    
  • 1ncx, 1ncz, 1top – cTnC
    
  • 1pon, 1cta, 1ctd – cTnC fragment – NMR
    
  • 1tnp - cTnC N-terminal – NMR
    
  • 1tnw, 1tnx - cTnC +Ca - NMR
    
  • 1trf - tTnC N-terminal+Ca - turkey – NMR
    
  • 5tnc - tTnC
    
  • 2k2a - TnC C-terminal – Lethocerus indicus – NMR
    
  • 2jnf – TnC – fly – NMR
    
  • 1r2u, 1r6p - TnC N-terminal – trout – NMR
    
• Troponin I
  • 2jpw – mTnI biphosphorylated – NMR
    
  • 1vdi – cTnI – NMR
    
  • 1vdj – cTnI+Ca - NMR
• Troponin T
  • 2z5h – yTnT fragment+tropomyosin – yeast

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Alexander Berchansky, Joel L. Sussman, Michal Harel