Sandbox Reserved 1606

This Sandbox is Reserved from Jan 13 through September 1, 2020 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1598 through Sandbox Reserved 1627.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

ABCG2 Multidrug Transporter

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Introduction The ABCG2 multidrug transporter is a membrane protein from the ATP-binding cassette (ABC) transporter family, specifically the G-subfamily. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, bloodtestis, and maternal-fetal barriers. ABCG2 protects cells by exporting xenobiotic molecules out of the cell using ATP hydrolysis. ABCG2 also affects the pharmacokinetics of many drugs and contributes to multidrug resistance. Function Transports xenobiotic molecules out of the cell (molecules that shouldn't be there) to protect cellular tissue (expand a bit/maybe combine intro and function?) Structural highlights ATP Bound and Unbound Conformations FIGURE LEGEND Disease Cancer ABCG2 contributes to multidrug resistance in cancer cells by exporting anti-tumor drugs out of cells which is an obstacle in cancer treatment. brief description of the cancer genes listed in the papers (papers talk about how some cancers had more expression of abcg2 genes) ABCG2 as a Target for Inhibition Talk about how and why it would be a good target for the treatment of cancer This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.