6rs4 | pdb_00006rs4

Structure of tabersonine synthase - an alpha-beta hydrolase from Catharanthus roseus

spinqualitylabelsall models 6rs4, resolution 1.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6rs4 is a 2 chain structure with sequence from Catro. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO Gene: TS, HL2 (CATRO) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [TS_CATRO] Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to tabersonine, a precursor of vindoline. Publication Abstract from PubMed Cycloaddition reactions generate chemical complexity in a single step. Here we report the crystal structures of three homologous plant-derived cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids. These enzymes act on the same substrate, named angryline, to generate three distinct scaffolds. Mutational analysis reveals how these highly similar enzymes control regio- and stereo-selectivity. Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids.,Caputi L, Franke J, Bussey K, Farrow SC, Vieira IJC, Stevenson CEM, Lawson DM, O'Connor SE Nat Chem Biol. 2020 Feb 17. pii: 10.1038/s41589-019-0460-x. doi:, 10.1038/s41589-019-0460-x. PMID:32066966 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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