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Function
Condensin or structural maintenance of chromosome protein (SMC) is required for correctly package and divide the cell's genome. SMC uses ATP to affect conformational changes in DNA, to correct DNA compaction, organization and segregation[1]. SMC exhibits the ability to super-coil DNA[2].
Disease
Relevance
SMC plays important role in human disease and bacterial pathogenicity and its inhibitors are studied for therapeutic purposes[3].
Structural highlights
SMC is a multisubunit complex.
- ↑ Kalitsis P, Zhang T, Marshall KM, Nielsen CF, Hudson DF. Condensin, master organizer of the genome. Chromosome Res. 2017 Mar;25(1):61-76. doi: 10.1007/s10577-017-9553-0. Epub 2017, Feb 9. PMID:28181049 doi:https://dx.doi.org/10.1007/s10577-017-9553-0
- ↑ Thadani R, Uhlmann F, Heeger S. Condensin, chromatin crossbarring and chromosome condensation. Curr Biol. 2012 Dec 4;22(23):R1012-21. doi: 10.1016/j.cub.2012.10.023. PMID:23218009 doi:https://dx.doi.org/10.1016/j.cub.2012.10.023
- ↑ Zhao H, Petrushenko ZM, Walker JK, Baudry J, Zgurskaya HI, Rybenkov VV. Small Molecule Condensin Inhibitors. ACS Infect Dis. 2018 Dec 14;4(12):1737-1745. doi: 10.1021/acsinfecdis.8b00222., Epub 2018 Oct 22. PMID:30346684 doi:https://dx.doi.org/10.1021/acsinfecdis.8b00222
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3D Structures of condensin
Updated on 02-April-2020
- Condensin or Structural Maintenance of Chromosome Protein; Domains - head 1-219+983-1186
4u4p – hSMC2 hinge domain 506-666 + SMC4 hinge domain 595-752 – human
6igx – hSMC subunit 2+3
3l51 – SMC2 hinge domain 506-666 + SMC4 hinge domain 595-752 – mouse
5oqq – ySMC subunit 2+3 – yeast
5oqn, 5oqo, 5oqp – ySMC subunit 2+3 + DNA
5oqr – SMC subunit 2+3 – fission yeast
6q6e – CtSMC residues 112-209 – Chaetomium thermophilum - NMR
6qj3 – CtSMC subunit 1+2 + Brn1
6qj4 – CtSMC subunit 1+2 + Brn1 + protein
6qj0, 6qj1 – CtSMC head domain
6qj2 – CtSMC head domain + Brn1
3zgx – BsSMC head domain + segregation and condensation protein – Bacillus subtilis
5xg3 – BsSMC head domain (mutant)+ coiled-coil domain + segregation and condensation protein
1xew – PfSMC head domain – Pyrococcus furiosus
1xex – PfSMC head domain (mutant)
4i99 – PfSMC head domain residues 1-182, 1006-1176 + protein
5xns – PfSMC head domain residues 1-219, 983-1186 + segregation and condensation protein
5xg2 – PySMC coiled-coil domain – Pyrococcus yayanosii
5xei – PySMC head+coiled-coil domains –
- Structural Maintenance of Chromosome-related Protein or Chromosome partition protein
- 2wmm – EcMukB hinge domain 645-804 (mutant) - Escherichia coli
- 4mn4 – EcMukB hinge domain 645-804 * DNA topoisomerase 4 subunit A
References
