6mjy | pdb_00006mjy

M. thermoresistible GuaB2 delta-CBS in complex with 6Cl-IMP

spinqualitylabelsall models 6mjy, resolution 1.56Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6mjy is a 1 chain structure with sequence from Atcc 19527. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CPR Gene: guaB, RMCT_0580 (ATCC 19527) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [A0A100XBM0_MYCTH] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] Publication Abstract from PubMed Inosine-5'-monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme involved in nucleotide biosynthesis. Because of its critical role in purine biosynthesis, IMPDH is a drug design target for immunosuppressive, anticancer, antiviral and antimicrobial chemotherapy. In this study, we use mass spectrometry and X-ray crystallography to show that the inhibitor 6-Cl-purine ribotide forms a covalent adduct with the Cys-341 residue of Mycobacterium thermoresistibile IMPDH. Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH).,Trapero A, Pacitto A, Chan DS, Abell C, Blundell TL, Ascher DB, Coyne AG Bioorg Med Chem Lett. 2020 Jan 15;30(2):126792. doi: 10.1016/j.bmcl.2019.126792. , Epub 2019 Nov 9. PMID:31757668 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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