3j1x | pdb_00003j1x

A refined model of the prototypical Salmonella typhimurium T3SS basal body reveals the molecular basis for its assembly

Loading... Status: waiting for Mol* initialization Structural highlights 3j1x is a 24 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 4g08, 4g1i, 3j1v, 3j1w Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PRGH_SALTY] Required for invasion of epithelial cells. Publication Abstract from PubMed Type III secretion systems (T3SSs) are essential virulence factors used by many Gram-negative bacteria to inject proteins that make eukaryotic host cells accessible to invasion. The T3SS core structure, the needle complex (NC), is a ~3.5 megadalton-sized, oligomeric, membrane-embedded complex. Analyzing cryo-electron microscopy images of top views of NCs or NC substructures from Salmonella typhimurium revealed a 24-fold symmetry for the inner rings and a 15-fold symmetry for the outer rings, giving an overall C3 symmetry. Local refinement and averaging showed the organization of the central core and allowed us to reconstruct a subnanometer composite structure of the NC, which together with confident docking of atomic structures reveal insights into its overall organization and structural requirements during assembly. Three-dimensional model of Salmonella's needle complex at subnanometer resolution.,Schraidt O, Marlovits TC Science. 2011 Mar 4;331(6021):1192-5. PMID:21385715 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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