5odv | pdb_00005odv

Structure of Watermelon mosaic virus potyvirus.

Loading... Status: waiting for Mol* initialization Structural highlights 5odv is a 48 chain structure with sequence from Watermelon mosaic virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Potyviruses constitute the second largest genus of plant viruses and cause important economic losses in a large variety of crops; however, the atomic structure of their particles remains unknown. Infective potyvirus virions are long flexuous filaments where coat protein (CP) subunits assemble in helical mode bound to a monopartite positive-sense single-stranded RNA [(+)ssRNA] genome. We present the cryo-electron microscopy (cryoEM) structure of the potyvirus watermelon mosaic virus at a resolution of 4.0 A. The atomic model shows a conserved fold for the CPs of flexible filamentous plant viruses, including a universally conserved RNA binding pocket, which is a potential target for antiviral compounds. This conserved fold of the CP is widely distributed in eukaryotic viruses and is also shared by nucleoproteins of enveloped viruses with segmented (-)ssRNA (negative-sense ssRNA) genomes, including influenza viruses. Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses.,Zamora M, Mendez-Lopez E, Agirrezabala X, Cuesta R, Lavin JL, Sanchez-Pina MA, Aranda MA, Valle M Sci Adv. 2017 Sep 20;3(9):eaao2182. doi: 10.1126/sciadv.aao2182. eCollection 2017, Sep. PMID:28948231 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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