6by7 | pdb_00006by7

Folding DNA into a lipid-conjugated nano-barrel for controlled reconstitution of membrane proteins

Loading... Status: waiting for Mol* initialization Structural highlights 6by7 is a 118 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Building upon DNA origami technology, we introduce a method to reconstitute a single membrane protein into a self-assembled DNA nanobarrel that scaffolds a nanodisc-like lipid environment. Compared with the membrane-scaffolding-protein nanodisc technique, our approach gives rise to defined stoichiometry, controlled sizes, as well as enhanced stability and homogeneity in membrane protein reconstitution. We further demonstrate potential applications of the DNA nanobarrels in the structural analysis of membrane proteins. Folding DNA into a Lipid-Conjugated Nanobarrel for Controlled Reconstitution of Membrane Proteins.,Dong Y, Chen S, Zhang S, Sodroski J, Yang Z, Liu D, Mao Y Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2072-2076. doi: 10.1002/anie.201710147., Epub 2018 Jan 9. PMID:29266648 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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