6du8 | pdb_00006du8

Human Polycsytin 2-l1

Loading... Status: waiting for Mol* initialization Structural highlights 6du8 is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAG Gene: PKD2L1, PKD2L, PKDL, TRPP3 (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PK2L1_HUMAN] Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. Publication Abstract from PubMed We report the near atomic resolution (3.3 A) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1. Cryo-EM structure of the polycystin 2-l1 ion channel.,Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE Elife. 2018 Jul 13;7. pii: 36931. doi: 10.7554/eLife.36931. PMID:30004384 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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