6hcr | pdb_00006hcr

Synthetic Self-assembling ADDomer Platform for Highly Efficient Vaccination by Genetically-encoded Multi-epitope Display

Loading... Status: waiting for Mol* initialization Structural highlights 6hcr is a 60 chain structure with sequence from Ade03. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: L2 (ADE03) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeutics. We created ADDomer, an adenovirus-derived multimeric protein-based self-assembling nanoparticle scaffold engineered to facilitate plug-and-play display of multiple immunogenic epitopes from pathogens. We used cryo-electron microscopy at near-atomic resolution and implemented novel, cost-effective, high-performance cloud computing to reveal architectural features in unprecedented detail. We analyzed ADDomer interaction with components of the immune system and developed a promising first-in-kind ADDomer-based vaccine candidate to combat emerging Chikungunya infectious disease, exemplifying the potential of our approach. Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display.,Vragniau C, Bufton JC, Garzoni F, Stermann E, Rabi F, Terrat C, Guidetti M, Josserand V, Williams M, Woods CJ, Viedma G, Bates P, Verrier B, Chaperot L, Schaffitzel C, Berger I, Fender P Sci Adv. 2019 Sep 25;5(9):eaaw2853. doi: 10.1126/sciadv.aaw2853. eCollection 2019, Sep. PMID:31620562 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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