5f8z | pdb_00005f8z

The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1

spinqualitylabelsall models 5f8z, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5f8z is a 2 chain structure with sequence from Human. This structure supersedes the now removed PDB entry 4zj4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MRZ, SO4 Related: 5f8t, 5f8x Gene: KLKB1, KLK3 (HUMAN) Activity: Plasma kallikrein, with EC number 3.4.21.34 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. Function [KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. See Also Kallikrein 3D structures

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