5fy5 | pdb_00005fy5

Crystal structure of the catalytic domain of human JARID1B in complex with fumarate

spinqualitylabelsall models 5fy5, resolution 2.47Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5fy5 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, EPE, FUM, MN, ZN Related: 5fxv, 5fxw, 5fxx, 5fxz, 5fy0, 5fy1, 5fy4, 5fy7, 5fy8, 5fy9, 5fyb, 5fyc, 5fyh, 5fyi, 5fym, 5fys, 5fyt, 5fyu, 5fyv, 5fyy, 5fyz, 5fz0, 5fz1, 5fz3, 5fz4, 5fz6, 5fz7, 5fz8 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. See Also Jumonji domain-containing protein 3D structures Lysine-specific histone demethylase 3D structures

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