Activin

spinqualitylabelsall models Human activin A (PDB code 5hlz) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Activin A or inhibitin β chain A (ActA) is a member of the TGF-β superfamily that inhibits the proliferation of breast cancer cells. Activin interacts with activin receptors to induce phosphorylation of intracellular signalling molecules which regulate the transcription of many genes in a cell- and tissue-specific manner. Relevance There is a strong overexpression of activin A in inflammatory bowel disease. Activin A plays an important role in chronic rhinosinusitis inflammation. Structural highlights Activin is synthesyzed as a large precursor and its pro domain is cleaved proteolitically releasing a mature domain.

3D structures of activin A

5hlz, 5hly - hActA - human
2arv - hActA mature domain residues 311-426
1nys, 1nyu, 1s4y - hActA mature domain + Acvr2B LBD
2b0u, 2arp, 2p6a - hActA mature domain + follistatin
3b4v - hActA mature domain + follistatin-like 3

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Michal Harel, Jaime Prilusky