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Function
CTFR inhibitory factor (Cif) is a virulance factor which catalyzes epoxide hydrolysis. Pseudomonas aeruginosa secretes Cif which causes the loss the ion channel Cystic Fibrosis Transmembrane conductance Regulator (CFTR) which is required for airway mucocilliary defense of the host cell[1].
Disease
Relevance
Structural highlights
- ↑ Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR. Inhibiting an epoxide hydrolase virulence factor from Pseudomonas aeruginosa protects CFTR. Angew Chem Int Ed Engl. 2015 Jul 1. doi: 10.1002/anie.201503983. PMID:26136396 doi:https://dx.doi.org/10.1002/anie.201503983
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3D structures of CTFR inhibitory factor
Updated on 07-May-2020
3kd2 - PaCif - Pseudomonas aeruginosa
3kda, 4dm7, 4dln, 4dmf, 4dmh, 4dmk, 3pi6, 4dmc - PaCif (mutant)
5tnh, 5tng, 5tni, 5tnl, 5tnk, 5tnn, 5tnm, 5tnd, 5tnf, 5tne, 5tnp, 5tnr, 5tnq, 5tns, 5tnj, 5jyc, 4dno, 4dnf - PaCif (mutant) + intermediate
4ehb - PaCif (mutant) + epoxyhexane
4eus - PaCif + hexanediol
4yx9, 5hka, 5hkb, 5hk9 - PaCif + inhibitor
References
