| Structural highlights
Function
[TXWW_NAJKA] Modulates both nicotinic and muscarinic acetylcholine receptors (nAChR and mAChR/CHRM). On nAChR, acts as an orthosteric (competitive) antagonist. On mAChR, in presence of ACh, it partially inhibits the effect of ACh (allosteric antagonist), whereas in the absence of ACh, it activates the receptor (allosteric agonist). Exerts a myorelaxant effect, induces a dose-dependent decrease in blood pressure and an increase in heart rate in mice and rats.[1] [2] [3] [4]
References
- ↑ Utkin YN, Kukhtina VV, Kryukova EV, Chiodini F, Bertrand D, Methfessel C, Tsetlin VI. "Weak toxin" from Naja kaouthia is a nontoxic antagonist of alpha 7 and muscle-type nicotinic acetylcholine receptors. J Biol Chem. 2001 May 11;276(19):15810-5. Epub 2001 Feb 15. PMID:11279130 doi:https://dx.doi.org/10.1074/jbc.M100788200
- ↑ Ogay AY, Rzhevsky DI, Murashev AN, Tsetlin VI, Utkin YN. Weak neurotoxin from Naja kaouthia cobra venom affects haemodynamic regulation by acting on acetylcholine receptors. Toxicon. 2005 Jan;45(1):93-9. PMID:15581687 doi:https://dx.doi.org/10.1016/j.toxicon.2004.09.014
- ↑ Mordvintsev DY, Rodionov DI, Makarova MV, Kamensky AA, Levitskaya NG, Ogay AY, Rzhevsky DI, Murashev AN, Tsetlin VI, Utkin YN. Behavioural effects in mice and intoxication symptomatology of weak neurotoxin from cobra Naja kaouthia. Basic Clin Pharmacol Toxicol. 2007 Apr;100(4):273-8. PMID:17371532 doi:https://dx.doi.org/10.1111/j.1742-7843.2007.00045.x
- ↑ Mordvintsev DY, Polyak YL, Rodionov DI, Jakubik J, Dolezal V, Karlsson E, Tsetlin VI, Utkin YN. Weak toxin WTX from Naja kaouthia cobra venom interacts with both nicotinic and muscarinic acetylcholine receptors. FEBS J. 2009 Sep;276(18):5065-75. doi: 10.1111/j.1742-4658.2009.07203.x. Epub, 2009 Aug 4. PMID:19682302 doi:https://dx.doi.org/10.1111/j.1742-4658.2009.07203.x
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