Nerve growth factor

spinqualitylabelsall models Human NGF (pink, yellow) complex with glycosylated TrkA receptor (grey, green) )PDB code 2ifg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Nerve growth factor (NGF) belongs to the family of neurotrophins. NGF promotes survival and differentiation of sensory and sympathetic neurons. NGF signaling furthers neuroprotective and repair functions. NGF interacts with 2 transmembrane receptors - TrkA and p75. Relevance Increased cerebrospinal fluid levels of proNGF mark the onset of mild cognitive impairment and the transition to Alzheimer disease suggest that NGF is a potential Alzheimer biomarker.

3D structures of nerve growth factor

Updated on 13-May-2020

4edk, 4edw, 5jz7 - hβ-NGF + antibody - human
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1btg, 5lsd, 1sgf, 1bet - mNGF - mouse
4xpj, 4eax - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra

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Michal Harel, Alexander Berchansky