Nerve growth factor

spinqualitylabelsall models Human NGF (purple, khaki) complex with TrkA receptor domain 5 (azure, mustard) (PDB code 1www) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Nerve growth factor (NGF) belongs to the family of neurotrophins. NGF promotes survival and differentiation of sensory and sympathetic neurons. NGF signaling furthers neuroprotective and repair functions. NGF interacts with 2 transmembrane receptors - TrkA and p75. Relevance Increased cerebrospinal fluid levels of proNGF mark the onset of mild cognitive impairment and the transition to Alzheimer disease suggest that NGF is a potential Alzheimer biomarker. Structural highlights The 3D structure of the complex between human NGF and one of its receptors - TrkA - shows the receptor D-5 domain Ig-like structure flanking the NGF homodimer. Various side chains form the interaction between NGF and its receptor with a totally buried NGF Arg residue forming the strongest one.

3D structures of nerve growth factor

Updated on 13-May-2020

4edk, 4edw, 5jz7 - hβ-NGF + antibody - human
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1btg, 5lsd, 1sgf, 1bet - mNGF - mouse
4xpj, 4eax - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra

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Michal Harel, Alexander Berchansky