6ytq | pdb_00006ytq

Cryo-EM structure of a dimer of undecameric human CALHM4 in the presence of Ca2+

spinqualitylabelsall models 6ytq, resolution 4.02Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ytq is a 22 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CAHM4_HUMAN] Pore-forming subunit of a voltage-gated ion channel.[UniProtKB:Q8IU99] Publication Abstract from PubMed The transport of substances across the placenta is essential for the development of the fetus. Here, we were interested in the role of channels of the calcium homeostasis modulator (CALHM) family in the human placenta. By transcript analysis, we found the paralogs CALHM2, 4, and 6 to be highly expressed in this organ and upregulated during trophoblast differentiation. Based on electrophysiology, we found that activation of these paralogs differs from the voltage- and calcium-gated channel CALHM1. Cryo-EM structures of CALHM4 display decameric and undecameric assemblies with large cylindrical pore, while in CALHM6 a conformational change has converted the pore shape into a conus that narrows at the intracellular side, thus describing distinct functional states of the channel. The pore geometry alters the distribution of lipids, which occupy the cylindrical pore of CALHM4 in a bilayer-like arrangement whereas they have redistributed in the conical pore of CALHM6 with potential functional consequences. Cryo-EM structures and functional properties of CALHM channels of the human placenta.,Drozdzyk K, Sawicka M, Bahamonde-Santos MI, Jonas Z, Deneka D, Albrecht C, Dutzler R Elife. 2020 May 6;9. pii: 55853. doi: 10.7554/eLife.55853. PMID:32374262 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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