2n9q | pdb_00002n9q

Photoswitchable G-quadruplex

spinqualitylabelsall models 2n9q, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2n9q is a 4 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: K NonStd Res: AZW Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two-tetrad G-quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G-quadruplexes with K(+) ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para-para-substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G-quadruplex and an unstructured state after E-Z isomerization. Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.,Thevarpadam J, Bessi I, Binas O, Goncalves DP, Slavov C, Jonker HR, Richter C, Wachtveitl J, Schwalbe H, Heckel A Angew Chem Int Ed Engl. 2016 Feb;55(8):2738-42. doi: 10.1002/anie.201510269. Epub, 2016 Jan 25. PMID:26805928 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA