Structural highlights
5ily is a 1 chain structure with sequence from American tobacco. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | BTB, DPO, MG |
| Related: | 5ik0, 5ik6, 5ik9, 5ika, 5ikh, 5il3, 5il8, 5ild, 5ilh, 5ili, 5ilj, 5ilk, 5ilz, 5im1 |
| Gene: | EAS3, EAS4 (American tobacco) |
| Activity: | 5-epiaristolochene synthase, with EC number 4.2.3.61 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
