2uuu | pdb_00002uuu
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ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE IN P212121
Overview
Ether phospholipids are essential constituents of eukaryotic cell, membranes. Rhizomelic chondrodysplasia punctata type 3 is a severe, peroxisomal disorder caused by inborn deficiency of, alkyldihydroxyacetonephosphate synthase (ADPS). The enzyme carries out the, most characteristic step in ether phospholipid biosynthesis: formation of, the ether bond. The crystal structure of ADPS from Dictyostelium, discoideum shows a fatty-alcohol molecule bound in a narrow hydrophobic, tunnel, specific for aliphatic chains of 16 carbons. Access to the tunnel, is controlled by a flexible loop and a gating helix at the, protein-membrane interface. Structural and mutagenesis investigations, identify a cluster of hydrophilic catalytic residues, including an, essential tyrosine, possibly involved in ... [(full description)]
About this Structure
2UUU is a [Single protein] structure of sequence from [Dictyostelium discoideum] with FAD and PL3 as [ligands]. Active as [[1]], with EC number [2.5.1.26]. Full crystallographic information is available from [OCA].
Reference
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder., Razeto A, Mattiroli F, Carpanelli E, Aliverti A, Pandini V, Coda A, Mattevi A, Structure. 2007 Jun;15(6):683-92. PMID:17562315
Page seeded by OCA on Mon Oct 29 17:50:59 2007
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Dictyostelium discoideum
- Single protein
- Aliverti, A.
- Carpanelli, E.
- Coda, A.
- Mattevi, A.
- Mattiroli, F.
- Pandini, V.
- Razeto, A.
- FAD
- PL3
- Biosynthesis of phospholipids
- Fad
- Flavin
- Flavoprotein
- Lipid synthesis
- Peroxisomal disorder
- Peroxisome
- Plasmalogens
- Rhizomelic chondrodysplasia punctata
- Transferase
