5l72 | pdb_00005l72

PI3 kinase delta in complex with N-[6-(5-methanesulfonamido-6-methoxypyridin-3-yl)-1,3-dihydro-2-benzofuran-4-yl]-2-(morpholin-4-yl)acetamide

spinqualitylabelsall models 5l72, resolution 3.06Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5l72 is a 1 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 6PF Gene: Pik3cd (LK3 transgenic mice) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed A four step process of high quality modelling of existing data, deconstruction, identification of replacement cores and an innovative synthetic re-growth strategy led to the rapid discovery of a novel oral series of PI3K delta inhibitors with promising selectivity and excellent in vivo characteristics. Evolution of a novel orally bioavailable series of PI3K delta inhibitors from an inhaled lead for the treatment of respiratory disease.,Amour A, Barton N, Cooper AW, Inglis G, Jamieson C, Luscombe CN, Perez D, Peace S, Rowland P, Tame C, Uddin S, Vitulli G, Wellaway N J Med Chem. 2016 Jul 18. PMID:27429068 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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