6wlb | pdb_00006wlb

Structure of homotrimeric poplar cellulose synthase isoform 8

spinqualitylabelsall models 6wlb, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6wlb is a 3 chain structure with sequence from Hybrid aspen. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BGC Gene: CesA3-1 (Hybrid aspen) Activity: Cellulose synthase (UDP-forming), with EC number 2.4.1.12 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Cellulose is an essential plant cell wall component and represents the most abundant biopolymer on Earth. Supramolecular plant cellulose synthase complexes organize multiple linear glucose polymers into microfibrils as load-bearing wall components. We determined the structure of a poplar cellulose synthase CesA homotrimer that suggests a molecular basis for cellulose microfibril formation. This complex, stabilized by cytosolic plant conserved regions and helical exchange within the transmembrane segment, forms three channels occupied by nascent cellulose polymers. Secretion steers the polymers toward a common exit point, which may facilitate protofibril formation. CesAs' N-terminal domains assemble into a cytosolic stalk that interacts with a microtubule-tethering protein and may thus be involved in CesA localization. Our data suggest how cellulose synthase complexes assemble and provide the molecular basis for plant cell wall engineering. Architecture of a catalytically active homotrimeric plant cellulose synthase complex.,Purushotham P, Ho R, Zimmer J Science. 2020 Jul 9. pii: science.abb2978. doi: 10.1126/science.abb2978. PMID:32646917 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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