|
Function
Fascin (FASC) is an actin microfilament cross-linking and bundling protein in mammalian cells. At least 3 fascins are known. FASC 1 is expressed in multiple cells while FASC 2 is found mostly in retina and FASC 3 in testis[1].
Disease
There is a direct relation between FASC expression in breast cancer patients and metastasis and shorter disease-free
survival[2].
Relevance
FASC is overexpresed in inflammatory bowel disease[3].
Structural highlights
- ↑ Gungor-Ordueri NE, Cheng CY. Fascin - An actin binding and bundling protein in the testis and its role in ectoplasmic specialization dynamics. Spermatogenesis. 2015 Feb 23;5(1):e1002733. doi: 10.1080/21565562.2014.1002733., eCollection 2015 Jan-Apr. PMID:26413410 doi:https://dx.doi.org/10.1080/21565562.2014.1002733
- ↑ Al-Alwan M, Olabi S, Ghebeh H, Barhoush E, Tulbah A, Al-Tweigeri T, Ajarim D, Adra C. Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules. PLoS One. 2011;6(11):e27339. doi: 10.1371/journal.pone.0027339. Epub 2011 Nov 4. PMID:22076152 doi:https://dx.doi.org/10.1371/journal.pone.0027339
- ↑ Qualtrough D, Smallwood K, Littlejohns D, Pignatelli M. The actin-bundling protein fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair. BMC Gastroenterol. 2011 Feb 23;11:14. doi: 10.1186/1471-230X-11-14. PMID:21345224 doi:https://dx.doi.org/10.1186/1471-230X-11-14
|
3D structures of fascin
1dfc, 3llp, 3p53 - hFASC 1 - human
4gov, 4goy, 4gp0, 4gp3 - hFASC 1 (mutant)
6i0z, 6i17, 6i16, 6i18, 6i11, 6i10, 6i13, 6i12, 6i15, 6i14 - hFASC + anti-metastatic inhibitor
6b0t - hFASC + inhibitor
References
