Structural highlights
5vmb is a 1 chain structure with sequence from Aciba. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Gene: | glyA, glyA2, A7M79_08275, A7M90_04720, A7N09_12635, A8A08_14715, A8G88_00905, AB895_0334, AB988_4249, ABUW_1333, APD06_10955, AZE33_14190, BGC29_02480, IX87_07645, LV38_04033 (ACIBA) |
| Activity: | Glycine hydroxymethyltransferase, with EC number 2.1.2.1 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[V5VBJ2_ACIBA] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
See Also
