5wpw | pdb_00005wpw

Crystal structure of coconut allergen cocosin

spinqualitylabelsall models 5wpw, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5wpw is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Coconut (Cocos nucifera) is an important palm tree. Coconut fruit is widely consumed. The most abundant storage protein in coconut fruit is cocosin (a likely food allergen), which belongs to the 11S globulin family. Cocosin was crystallized near a century ago, but its structure remains unknown. By optimizing crystallization conditions and cryoprotectant solutions, we were able to obtain cocosin crystals that diffracted to 1.85 A. The cocosin gene was cloned from genomic DNA isolated from dry coconut tissue. The protein sequence deduced from the predicted cocosin coding sequence was used to guide model building and structure refinement. The structure of cocosin was determined for the first time, and it revealed a typical 11S globulin feature of a double layer doughnut-shaped hexamer. Crystal Structure of Cocosin, A Potential Food Allergen from Coconut (Cocos nucifera).,Jin T, Wang C, Zhang C, Wang Y, Chen YW, Guo F, Howard A, Cao MJ, Fu TJ, McHugh TH, Zhang Y J Agric Food Chem. 2017 Aug 30;65(34):7560-7568. doi: 10.1021/acs.jafc.7b02252., Epub 2017 Jul 31. PMID:28712292 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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